کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5560147 1403309 2017 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Coatings in food contact materials: Potential source of genotoxic contaminants?
ترجمه فارسی عنوان
پوشش مواد تماس با مواد: منبع پتانسیل آلاینده های ژنوتیک؟
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
چکیده انگلیسی


- 1976 substances with no (recent) toxicological evaluation may be used in coatings.
- 53 substances are predicted genotoxic in both ToxTree and Derek Nexus™.
- 10 high concern substances based on in vivo genotoxicity and/or CMR classification.
- Urgent need to investigate actual use of ten high concern substances in coatings.

Up till now, no harmonized EU regulation exists on chemicals used in coatings for food contact materials (FCM). Therefore, these substances need to comply with the general provisions of EU Regulation 1935/2004 and, if present, with national legislation. Different 'inventory lists' of compounds that might be present in coatings are available, but for hundreds of these substances, the potential human health impact of their use in FCM coatings has not (recently) been evaluated. Since detailed evaluation of all compounds is not feasible, a pragmatic approach was developed to identify substances with a potential concern for human health. First, an inventory was assembled containing all substances potentially used in coatings. Afterwards, the genotoxic potential of the non-evaluated substances was predicted in silico using two structure-activity relationship (SAR) software programs. For substances yielding structural alerts in both models, genotoxicity data were collected from previous European evaluations in a non-FCM context and from the European CHemicals Agency (ECHA) website. In total, 53 substances were identified as genotoxic in both in silico models, of which ten were considered to be of high concern. For most of the substances, additional toxicological information is needed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 106, Part A, August 2017, Pages 496-505
نویسندگان
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