کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5560194 | 1561740 | 2017 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Lack of genotoxicity in vivo for food color additive Allura Red AC
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کلمات کلیدی
SCFAllura Red ACFD&CJECFAGLPINSMMSOECDNCEMNPCEPCEUS FDA - FDA ایالات متحدهGood Laboratory Practices - آزمایشات خوبEuropean Union - اتحادیه اروپاEuropean Food Safety Authority - اداره ایمنی اروپاUnited States Food and Drug Administration - اداره غذا و داروی ایالات متحدهpolychromatic erythrocytes - اریتروسیت های چند رنگیnormochromatic erythrocytes - اریتروسیتهای نورموشروماتیکFood color - رنگ غذاOrganisation for Economic Co-operation and Development - سازمان همکاری اقتصادی و توسعهGenotoxicity - سمیت ژنتیکیCyclophosphamide - سیکلوفسفامید methyl methanesulfonate - متیل متان سولفوناتJoint FAO/WHO Expert Committee on Food Additives - مجمع متخصص FAO / WHO در مورد مواد افزودنی مواد غذایی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Allura Red AC is an approved food color additive internationally with INS number 129, in the United States as food color subject to batch certification “Food, Drug, and Cosmetic” (FD&C) Red No. 40, and in Europe as food color additive with E number 129. In their evaluation of the color (2013), the European Food Safety Authority (EFSA) expressed concerns of potential genotoxicity, based primarily on one genotoxicity study that was not conducted according to Guidelines. The present in vivo genotoxicity study was conducted according to OECD Guidelines in response to EFSA's request for additional data. The animal species and strain, and the tissues examined were selected specifically to address the previously reported findings. The results show clear absence of genotoxic activity for Allura Red AC, in the bone marrow micronucleus assay and the Comet assay in the liver, stomach, and colon. These data addressed EFSA's concerns for genotoxicity. The Joint WHO/FAO Committee on Food Additives (JECFA) (2016) also reviewed the study and concluded that there is no genotoxicity concern for Allura Red AC. Negative findings in parallel genotoxicity studies on Tartrazine and Ponceau 4R (published separately) are consistent with lack of genotoxicity for azo dyes used as food colors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 105, July 2017, Pages 308-314
Journal: Food and Chemical Toxicology - Volume 105, July 2017, Pages 308-314
نویسندگان
Maria Ph.D., Thomas Ph.D., Sachin B.V.Sc & AH, Ph.D., DABT, Kamala M.S., Rohan M.Sc., Ph.D.,