کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5584917 | 1568005 | 2016 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Changes in relative and absolute concentrations of plasma phospholipid fatty acids observed in a randomized trial of Omega-3 fatty acids supplementation in Uganda
ترجمه فارسی عنوان
تغییرات غلظت نسبی و مطلق اسیدهای چرب فسفولیپید پلاسما در یک آزمایش تصادفی از مکمل های اسید چرب امگا 3 در اوگاندا
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کلمات کلیدی
EPADPAUCIHOSOPLFARelative concentrationEicosapentaenoic acid - اسید ایکوزاپنتانوئیکdocosapentaenoic acid - اسید داکوزاپنتانوئیکdocosahexaenoic acid - اسید داکوزاگزوائونیکphospholipid fatty acid - اسید چرب فسفولیپیدDHA - دوکوساهگزائنوئیک اسیدKaposi’s sarcoma - سارکوم کاپوسیCoefficient of Variation - ضریب تغییرGas chromatography - کروماتوگرافی گازیquality control - کنترل کیفیت
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیوشیمی بالینی
چکیده انگلیسی
Expressing circulating phospholipid fatty acids (PLFAs) in relative concentrations has some limitations: the total of all fatty acids are summed to 100%; therefore, the values of individual fatty acid are not independent. In this study we examined if both relative and absolute metrics could effectively measure changes in circulating PLFA concentrations in an intervention trial. 66 HIV and HHV8 infected patients in Uganda were randomized to take 3Â g/d of either long-chain omega-3 fatty acids (1856Â mg EPA and 1232Â mg DHA) or high-oleic safflower oil in a 12-week double-blind trial. Plasma samples were collected at baseline and end of trial. Relative weight percentage and absolute concentrations of 41 plasma PLFAs were measured using gas chromatography. Total cholesterol was also measured. Intervention-effect changes in concentrations were calculated as differences between end of 12-week trial and baseline. Pearson correlations of relative and absolute concentration changes in individual PLFAs were high (>0.6) for 37 of the 41 PLFAs analyzed. In the intervention arm, 17 PLFAs changed significantly in relative concentration and 16 in absolute concentration, 15 of which were identical. Absolute concentration of total PLFAs decreased 95.1Â mg/L (95% CI: 26.0, 164.2; P=0.0085), but total cholesterol did not change significantly in the intervention arm. No significant change was observed in any of the measurements in the placebo arm. Both relative weight percentage and absolute concentrations could effectively measure changes in plasma PLFA concentrations. EPA and DHA supplementation changes the concentrations of multiple plasma PLFAs besides EPA and DHA.Both relative weight percentage and absolute concentrations could effectively measure changes in plasma phospholipid fatty acid (PLFA) concentrations.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - Volume 114, November 2016, Pages 11-16
Journal: Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) - Volume 114, November 2016, Pages 11-16
نویسندگان
Xiaoling Song, Pho Diep, Jeannette M. Schenk, Corey Casper, Jackson Orem, Zeina Makhoul, Johanna W. Lampe, Marian L. Neuhouser,