کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5588495 1569042 2017 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Higher free triiodothyronine is associated with non-alcoholic fatty liver disease in euthyroid subjects: the Lifelines Cohort Study
ترجمه فارسی عنوان
سهیمیه تری تیرونین آزاد با بیماری کبدی چرب غیر الکلی در افراد مبتلا به ائوتیروئید همراه است: مطالعه کوهورت لیفلینز
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی

ObjectiveOvert hypothyroidism confers an increased risk of non-alcoholic fatty liver disease (NAFLD). The liver plays a crucial role in the metabolism of cholesterol and triglycerides; thyroid hormones interact on hepatic lipid homeostasis. Thyroid function within the euthyroid range affects a number of health issues, including atherosclerosis development and biochemical markers of increased cardiovascular risk. However, the association of thyroid hormones with NAFLD in euthyroid subjects has not been unequivocally established. We therefore determined associations of thyroid hormone parameters with NAFLD among euthyroid subjects.MethodsThe study was conducted in the Lifelines Cohort Study, a population-based cohort study of participants living in the North of the Netherlands. Only euthyroid subjects (thyroid-stimulating hormone (TSH) 0.5-4.0 mU/L, free thyroxine (FT4) 11-19.5 pmol/L and free triiodothyronine (FT3) 4.4-6.7 pmol/L) older than 18 years were included. Exclusion criteria were participants with excessive alcohol use, known hepatitis or cirrhosis, liver functions ≥ three times the upper limit, current cancer, non-white ancestry, previous or current use of thyroid medication and current use of lipid or glucose lowering medication. A priori defined liver biochemistry, thyroid function parameters and metabolic syndrome (MetS) were studied. NAFLD was defined by using the validated Fatty Liver Index (FLI); FLI ≥ 60 was categorized as NAFLD. A P < 0.01 was considered significant.ResultsFLI ≥ 60 was found in 4274 (21.1%) of 20,289 individuals (62.1% male, median age 46 years) with increased prevalence of MetS (P < 0.0001). In age- and sex-adjusted analysis FLI ≥ 60 was independently associated with a higher FT3 (OR 1.34, 95% CI 1.29-1.39, per SD increment, P < 0.0001) and a lower FT4 (OR 0.73, 95% CI 0.70-0.75, P < 0.0001) but not by TSH. The strongest association was found for the FT3/FT4 ratio (OR 1.44, 95% CI 1.39-1.49, P < 0.0001). These associations remained similar after additional adjustment for the presence of MetS. In subjects with enlarged waist circumference, TSH and FT4 were lower while FT3 was higher, resulting in an increased FT3/FT4 ratio (P < 0.0001).ConclusionsEuthyroid subjects with suspected NAFLD are characterized by higher FT3, lower FT4 and higher FT3/FT4 ratio, probably consequent to central obesity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Metabolism - Volume 67, February 2017, Pages 62-71
نویسندگان
, , , , , , ,