ReviewAnalysis of pre- and post-pregnancy issues in women with hyperemesis gravidarum

- Cases with HG are more likely than controls to report 30 pre-existing conditions.
- Cases with HG are more likely to report 57 post-pregnancy conditions.
- Novel pre-existing issues identified include motion sickness and dental issues.
- Significant post-pregnancy psychosocial issues include missed work (68%).
- Physical issues were physical condition, irregular periods, and stretchmarks.

The purpose of this study is to determine the frequency of reporting of both pre-pregnancy and post-pregnancy psychosocial and physical issues in women with hyperemesis gravidarum (HG). Conditions in 449 women with HG were compared to 459 unaffected women (controls). Binary responses were analyzed using either Chi-squared or Fishers Exact test. Continuous responses were analyzed using a t-test.Among 60 pre-pregnancy conditions surveyed, 10 common (> 5%) maternal pre-pregnancy conditions were significantly more frequently reported by women with HG. Twenty rare (< 5% controls) pre-pregnancy conditions with significantly increased reporting in the HG group were identified. Thirty (50%) pre-pregnancy conditions were similarly reported between cases and controls. Among 80 post-pregnancy factors surveyed, women with HG also showed significantly higher reporting for 7 common and 50 rare post-pregnancy outcomes. Women with HG are significantly more likely to self-report physical and psychosocial issues both before and after pregnancy.