کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5626339 1406316 2017 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Original articleCoexisting neuronal autoantibodies among children with demyelinating syndromes
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب تکاملی
پیش نمایش صفحه اول مقاله
Original articleCoexisting neuronal autoantibodies among children with demyelinating syndromes
چکیده انگلیسی

ObjectivesTo determine the incidence and clinical relevance of neuronal autoantibodies in children with demyelinating syndromes.MethodsWe conducted a prospective study including 31 consecutive children with demyelinating syndromes. Four patients with N-Methyl-D-aspartate receptor (NMDAR) encephalitis, 32 patients with Guillain-Barre syndrome, 13 children with benign childhood epilepsy, and 28 healthy children were used as controls. Prior to initiating immunomodulatory therapy, serum samples were tested for antibodies against NMDAR, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) 1, AMPAR2, leucine-rich glioma-activated protein 1, contactin-associated protein 2, gamma-aminobutyric acid B receptors, paraneoplastic ma antigen 2 (PNMA2/Ta), Yo, Ri, Hu, CV2, amphiphysin, and aquaporin-4 by indirect immunofluorescence assays.ResultsThree anti-neuronal antibodies were detected; NMDAR antibody in one with multiple sclerosis, PNMA2/Ta antibody in one with multiple sclerosis, and Yo antibody in one with clinically isolated syndrome. The positivity rate of neuronal autoantibodies in demyelinating syndrome was 10%. All seropositive patients were found to be negative for tumor screening. None of these patients exhibited symptoms of encephalitis.ConclusionChildren with demyelinating syndromes without symptoms of encephalitis can be positive for anti-neuronal antibodies.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain and Development - Volume 39, Issue 3, March 2017, Pages 248-251
نویسندگان
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