Oxidant and anti-oxidant status in common brain tumors: Correlation to TP53 and human biliverdin reductase

- Reactive oxygen species may have a crucial role in the malignancy of common brain tumors.
- There may be a close relationship between ROS, TP53 and human BLRA in the generation of meningiomas and gliomas.
- Further studies will clarify the exact roles of mechanisms, which may help us to develop an effective molecular treatment.

ObjectiveTo assess oxidant and antioxidant status in patients with common brain tumors; namely meningiomas, low-grade gliomas (LGG) and high-grade gliomas (HGG) and to compare with normal brain tissues.Patients and methodsAlmost nine biomarkers were measured in 59 brain tumors obtained during surgery and 15 normal brain tissues that were collected during autopsy. Results were compared between two groups.ResultsIn general, protein oxidation and lipid peroxidation increased while antioxidant capacity decreased significantly in tumors compared to the controls (p < 0.05) and higher the grade of the tumor, higher the levels of oxidation and lower the anti-oxidation.ConclusionsReactive oxygen species may play a crucial role in the pathogenesis of these common brain tumors. As the processes at the molecular level understood, targeted-treatment adjunct to surgical removal will be possible to cope with these devastating brain tumors.