Monitoring cardiac and respiratory physiology during FMRI

- An overview of tips, advice and collected wisdom for acquiring physiological data.
- A guide to diagnosing artefacts and issues with respiratory stimuli for FMRI.
- The what and the how of incorporating physiological data into FMRI analysis.

This article will consider how physiological monitoring can be used both as an intrinsic part of an experiment, or for removing unwanted physiological signals from the FMRI time series. As functional MRI is used for a wide variety of applications beyond the identification of regions involved in a task, different sources of noise in the time series become important. The use of arterial spin labelling sequences, either in isolation or combined with BOLD imaging, means that temporal noise must be dealt with differently. Moreover, when these are combined with global cerebrovascular stimuli, such as respiratory challenges, the standard analysis tools must be employed with great care so as not to detrimentally distort the data. Acquiring and analysing physiological data is sometimes more art than science, and this article attempts to provide some insight into common techniques as well as advice on identifying and correcting some of the problems that may be encountered.