کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5640460 | 1406819 | 2016 | 4 صفحه PDF | دانلود رایگان |
Background/purposeRecurrent aphthous stomatitis (RAS) is a common oral mucosal disease. Recently, oxidative stress has been thought to play a major role in the etiopathogenesis of RAS. The aim of this investigation was to compare the serum levels of an important oxidant agent [malondialdehyde (MDA)] and nonenzymatic antioxidants [uric acid (UA) and vitamins C and E] in patients with RAS versus healthy individuals.Materials and methodsNinety-seven patients with idiopathic minor RAS and 97 race-, age-, and sex-matched healthy individuals were included in this study. All these individuals were allocated to three groups: RAS patients in the active stage (Group A); the same RAS patients in Group A in the remission stage (Group B); and healthy individuals without RAS (Group C). The serum levels of MDA, UA, and vitamins C and E were measured by the spectrophotometric method. Independent sample t test and paired t test were performed for statistical evaluation.ResultsSerum MDA level of Group A was significantly higher than that of Group B (PÂ =Â 0.040) or Group C (PÂ =Â 0.011), whereas the serum level of vitamin E was significantly decreased in Group A as compared with Group B (PÂ =Â 0.012) or Group C (PÂ =Â 0.001). No statistically significant differences were found between Group B and Group C in terms of MDA, UA, and vitamins C and E serum levels (PÂ >Â 0.05).ConclusionWith the double-faced character of oxidant/antioxidant, UA and vitamin C may not play a crucial role in the pathogenesis of RAS. However, MDA and vitamin E can be used as indicators for RAS.
Journal: Journal of Dental Sciences - Volume 11, Issue 4, December 2016, Pages 401-404