کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5655649 | 1407324 | 2017 | 5 صفحه PDF | دانلود رایگان |
BackgroundNAFLD and vitamin D deficiency often coexist and epidemiologic evidence has shown that both of these conditions share several risk factors. Recent studies investigating the relationship between vitamin D levels and severity of NAFLD showed conflicting results. Thus we conducted a systematic review and meta-analysis to evaluate association between vitamin D and NAFLD histologic severity.MethodsA comprehensive search of the databases of the MEDLINE and EMBASE was performed from inception through November 2016. Observational studies compared serum vitamin D levels among NAFLD patients with high and low histologic severity, which was determined by NAFLD activity score (NAS) and fibrosis score. We calculated pooled mean difference (MD) of 25-hydroxyvitamin D levels with 95% confidence intervals (CI) using random-effects model.ResultsData were extracted from 6 studies involving 974 NAFLD patients. There was no difference in 25-hydroxyvitamin D levels among NAFLD patients with high NAS (score of â¥5) versus low NAS (pooled MD = â0.93, 95%CI â2.45 to 0.58, I2 = 0%) and also high fibrosis score (score of â¥3) versus low fibrosis score (pooled MD = 0.88, 95%CI â2.65 to 4.42, I2 = 64%).ConclusionsDespite evidence implicating vitamin D in NAFLD pathogenesis, serum 25-hydroxyvitamin D may not be associated with NAFLD histologic severity.
Journal: Digestive and Liver Disease - Volume 49, Issue 6, June 2017, Pages 618-622