کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5656825 1589654 2018 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Enteral feeding with low-methoxyl pectin accelerates colonic anastomosis healing in rats
ترجمه فارسی عنوان
تغذیه اینتالپتیک با پکتین کم متاکسیل باعث بهبودی التهاب آناستوموز کولون در موش صحرایی می شود
کلمات کلیدی
تغذیه انتالال، شکستن قدرت، استرسهای فیزیکی، اسیدهای چرب کوتاه مدت،
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
چکیده انگلیسی


- The present study investigated the effects of structurally different pectins, low-methoxyl pectin (LMP) or high-methoxyl pectin (HMP), on colonic anastomosis healing in rats.
- A major finding was that anastomosis breaking strength in rats fed the LMP diet was the highest and normally formed stools were observed only in the LMP group.
- LMP promotes healing of colonic anastomosis more effectively than HMP, which may be explained by the mechanical stresses generated by the movement of normally formed stool though the colon.

ObjectiveEnteral feeding with pectin has proven beneficial for anastomosis healing in rats. The aim of this study was to investigate the effects of low-methoxyl pectin (LMP) or high-methoxyl pectin (HMP), on colonic anastomosis healing in rats.MethodsMale Sprague-Dawley rats (age 7 wk) were fed liquid diets containing LMP, HMP, or no pectin (pectin-free [PF]) for 14 d (n = 10/group). The rats underwent colonic anastomosis surgery on day 7 and were sacrificed on day 14. Bursting pressure, breaking strength, and salt-soluble hydroxyproline at the anastomosis site were used as indices of anastomosis healing. Short-chain fatty acids (SCFAs) in the cecal contents were analyzed.ResultsBreaking strength was higher in the LMP group than in the other two groups (P < 0.001). The salt-soluble hydroxyproline content was higher in LMP group than in the PF group (P < 0.01). Bursting pressure did not differ among the three groups. The LMP group produced normal, formed stools, whereas watery stools were observed in HMP and PF groups throughout the experimental period. Cecal SCFAs were highest in LMP group.ConclusionsThese results suggest that LMP promotes healing of colonic anastomosis more effectively than HMP, which may be explained by the mechanical stresses generated by the movement of normally formed stool though the colon.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nutrition - Volume 45, January 2018, Pages 94-98
نویسندگان
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