کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5668236 1592395 2017 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Systemic antimicrobial prophylaxis in burn patients: systematic review
ترجمه فارسی عنوان
پیشگیری بیماریهای ضد میکروبی سیستمیک در بیماران سوختگی: بررسی سیستماتیک
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
چکیده انگلیسی

SummaryObjectiveTo review studies of systemic antibiotic prophylaxis in burn patients.MethodsElectronic databases were searched for human clinical trials performed between 1966 and 2016 that compared prophylactic systemic antibiotics with placebo or no intervention.ResultsNineteen trials met the selection criteria. Early postburn prophylaxis was assessed in non-severe burn patients (six trials) and severe burn patients (seven trials). Antimicrobial prophylaxis showed no effectiveness for the prevention of toxic shock syndrome or burn wound infection (Grade 1C), but could be useful in patients with severe burns and requirement for mechanical ventilation (Grade 2B). Perioperative prophylaxis was assessed in six trials. Antimicrobial prophylaxis during resection of devitalized tissue is of no benefit in most burn patients (Grade 2B); however, there is insufficient evidence to make a recommendation for patients with extensive burns. Antibiotic prophylaxis may also be effective in preventing split-thickness skin graft infections in selected procedures (Grade 2B).ConclusionsThe available evidence does not support the role of systemic antibiotic prophylaxis in the management of the majority of burn patients. Nevertheless, it may be useful in patients with severe burns who require mechanical ventilation, and in selected split-thickness skin grafting procedures.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Hospital Infection - Volume 97, Issue 2, October 2017, Pages 105-114
نویسندگان
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