کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5685201 | 1409015 | 2017 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Toward a Comprehensive Hypothesis of Chronic Interstitial Nephritis in Agricultural Communities
ترجمه فارسی عنوان
به سوی یک فرض کلی در مورد نفریت مزمن بینی در جوامع کشاورزی
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای کلیوی
چکیده انگلیسی
Over the past 20Â years, there has been an increase in chronic interstitial nephritis in agricultural communities (CINAC) not associated with traditional risk factors. This disease has become an important public health problem and is observed in several countries in Central America and Asia. CINAC predominantly affects young male farmers between the third and fifth decades of life with women, children, and adolescents less often affected. Clinically, CINAC behaves like a chronic tubulointerstitial nephropathy but with systemic manifestations not attributable to kidney disease. Kidney biopsy reveals chronic tubulointerstitial nephritis with variable glomerulosclerosis and mild chronic vascular damage, with the severity depending on sex, occupation, and CKD stage. The presence of toxicological, occupational, and environmental risk factors within these communities suggests a multifactorial etiology for CINAC. This may include exposure to agrochemicals, a contaminated environment, repeated episodes of dehydration with heat stress, and an underlying genetic predisposition. An understanding of these interacting factors using a multidisciplinary approach with international cooperation and the formulation of a comprehensive hypothesis are essential for the development of public health programs to prevent this devastating epidemic.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Advances in Chronic Kidney Disease - Volume 24, Issue 2, March 2017, Pages 101-106
Journal: Advances in Chronic Kidney Disease - Volume 24, Issue 2, March 2017, Pages 101-106
نویسندگان
Carlos Manuel Orantes-Navarro, Raúl Herrera-Valdés, Miguel Almaguer-López, Laura López-MarÃn, Xavier Fernando Vela-Parada, Marcelo Hernandez-Cuchillas, Lilly M. Barba,