Original ContributionMethylation analysis of SHOX2 and RASSF1A in bronchoalveolar lavage fluid for early lung cancer diagnosis

- The consist rates of the SHOX2 and RASSF1A methylation tested by RT-PCR and sequencing were 99.0% and 100%;
- The methylation positive rate of SHOX2 and RASSF1A is significantly higher in the lung cancer group;
- The DNA methylation substantially enhanced the sensitivity and specificity of the cytological examination.