کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5737483 | 1614716 | 2017 | 36 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Differential effects of neonatal SSRI treatments on hypoxia-induced behavioral changes in male and female offspring
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کلمات کلیدی
UAOnorepinephrine transporterFLXPFC5-HIAADOPACPPIEPMFSTDAT3,4-dihydroxy-phenylacetic acid - 3،4-دی هیدروکسی فنیل اکتین اسید5-hydroxyindole acetic acid - 5-hydroxyindole اسید استیکOpen field test - آزمایش میدان بازforced swim test - آزمون شناور اجباریDopamine transporter - انتقال دهنده دوپامینuterine artery occlusion - انسداد شریان رحمelevated plus maze - بالا به همراه پیچ و خمNET - خالصESC - خروجDopamine - دوپامینBehavior - رفتارgestational day - روز بارداریSERT - سختSerotonin - سروتونینserotonin transporter - سروتونین حمل کنندهFluoxetine - فلوکستینprefrontal cortex - قشر prefrontalunconditioned stimulus - محرک بی قید و شرطconditioned stimulus - محرک شرطیIntervention - مداخلهSelective serotonin reuptake inhibitor - مهار کننده بازجذب سروتونین انتخابیSSRI - مهارکنندههای بازجذب سروتونینEscitalopram - همزمان escitalopramPrenatal hypoxia - هیپوکسی پیش از قاعدگیHPLC - کروماتوگرافی مایعی کاراhigh-performance liquid chromatography - کروماتوگرافی مایعی کارا
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Prenatal hypoxia induced by transient intrauterine ischemia is a serious clinical problem, and at present, effective treatments are lacking. Currently, it is unknown how prenatal hypoxia affects behaviors in adulthood. Therefore, we developed a mouse model that mimics prenatal hypoxia in humans using uterine artery occlusion in late gestation. We examined whether prenatal hypoxia induces behavioral changes in adult male and female offspring by conducting a series of behavioral tests. In adulthood, longer immobility was observed in the forced swim test in males, whereas females showed decreased inhibition in the prepulse inhibition test. We then investigated the effects of two different selective serotonin reuptake inhibitors (SSRIs), fluoxetine (FLX) and escitalopram (ESC), on these behavioral changes. These drugs affect the neurodevelopmental process and have long-term neurological consequences. FLX treatment from postnatal day 3 (P3) to P21 ameliorated the behavioral changes in both male and female mice. In comparison, ESC treatment ameliorated the behavioral changes only in female mice. Neurochemical analysis revealed that dopamine was increased in the female hippocampus, but not in males. Thus, neonatal SSRI treatment decreases dopamine levels in the hippocampus in females selectively. Our findings suggest that prenatal hypoxia is a risk factor for behavioral abnormalities in adulthood, and that neonatal SSRI treatment might have clinical potential for alleviating these long-term behavioral deficits.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 360, 30 September 2017, Pages 95-105
Journal: Neuroscience - Volume 360, 30 September 2017, Pages 95-105
نویسندگان
Reiko Nagano, Masatoshi Nagano, Akihito Nakai, Toshiyuki Takeshita, Hidenori Suzuki,