کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5737893 | 1614733 | 2017 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
TFP5 is comparable to mild hypothermia in improving neurological outcomes in early-stage ischemic stroke of adult rats
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کلمات کلیدی
cdk5/p35Cdk5/p25MMP9cdk5GAPDHMCAOTTC2,3,5-triphenyltetrazolium chloride - 2،3،5-trihenyltetrazolium chloridemiddle cerebral artery occlusion - انسداد شریان (سرخرگ) مغزی میانیIschemia - ایسکمیIHC - ایمونوهیستوشیمیImmunohistochemistry - ایمونوهیستوشیمیAlzheimer’s disease - بیماری آلزایمرParkinson's disease - بیماری پارکینسونBlood–brain barrier - سد خونی مغزیBBB - سد خونی مغزیStroke - سکته مغزیcyclin-dependent kinase 5 - سیکلین وابسته به کیناز 5matrix metallopeptidase 9 - ماتریکس متالوپپتیداز 9map - نقشهHypothermia - هیپوترمیMild hypothermia - هیپوترمی خفیفoptical density - چگالی نوریglyceraldehyde-3-phosphate dehydrogenase - گلیسرالیدید-3-فسفات دهیدروژناز
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Aim: We compared the efficacy of a modified truncated 24-aa peptide (TFP5), derived from the cyclin-dependent kinase 5 (CDK5)-activating cofactor p35, with mild hypothermia (MH), and determined whether the efficacy of TFP5 is affected by MH. Methods: Ischemic stroke was induced in adult male Sprague-Dawley rats for 2Â h. Immediately after initiating reperfusion, TFP5, MH, or the combination of the two were administrated. 48Â h after reperfusion, neurological outcomes were evaluated. Results: Rats that received either MH, TFP5, or the combined treatment showed smaller brain infarct size than normothermia control (NT), and there was no apparent difference among these three treatment groups. The neurological deficit was significantly improved only by the combined treatment. MH or TFP5 ameliorated the blood-brain barrier (BBB) disruption in ischemic regions with similar efficacy, whereas the combination of them had a trend toward better effect. Besides, the cleavage of p35 into p25 and apoptosis in ischemic regions was inhibited by TFP5 or the combination, but not by MH alone. Conclusions: TFP5 is comparable to MH in improving neurological outcomes in early-stage adult ischemic stroke. When TFP5 is given along with MH, less neurological deficit tends to be achieved.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 343, 20 February 2017, Pages 337-345
Journal: Neuroscience - Volume 343, 20 February 2017, Pages 337-345
نویسندگان
Ya-Bin Ji, Pei-Pei Zhuang, Zhong Ji, Kai-Bin Huang, Yong Gu, Yong-Ming Wu, Su-Yue Pan, Ya-Fang Hu,