کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5737965 | 1614730 | 2017 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Lactate and glutamate dynamics during prolonged stimulation of the rat barrel cortex suggest adaptation of cerebral glucose and oxygen metabolism
ترجمه فارسی عنوان
پویایی لاکتات و گلوتامات در طول تحرک طولانی قشر بطری موش صحرایی نشان می دهد که سازگاری متابولیسم گلوکز مغز و متابولیسم اکسیژن
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کلمات کلیدی
LACfunctional magnetic resonance spectroscopyfMRSTGNBOLDGLNS1BFVOI - CANvolume of interest - حجم سودAdaptation - سازگاری(زیست شناسی)blood oxygen level dependent - سطح اکسیژن خون وابسته استtrigeminal nerve - عصب سه گانهBarrel cortex - قشر بشکهLactate - لاکتاتGABA - گاباGlu - گلوglutamate - گلوتاماتglutamine - گلوتامین
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
چکیده انگلیسی
A better understanding of BOLD responses stems from a better characterization of the brain's ability to metabolize glucose and oxygen. Non-invasive techniques such as functional magnetic resonance spectroscopy (fMRS) have thus been developed allowing for the reproducible assessment of metabolic changes during barrel cortex (S1BF) activations in rats. The present study aimed at further exploring the role of neurotransmitters on local and temporal changes in vascular and metabolic function in S1BF. fMRS and fMRI data were acquired sequentially in α-chloralose anesthetized rats during 32-min rest and trigeminal nerve stimulation periods. During stimulation, concentrations of lactate (Lac) and glutamate (Glu) increased in S1BF by 0.23 ± 0.05 and 0.34 ± 0.05 μmol/g respectively in S1BF. Dynamic analysis of metabolite concentrations allowed estimating changes in cerebral metabolic rates of glucose (ÎCMRGlc) and oxygen (ÎCMRO2). Findings confirmed a prevalence of oxidative metabolism during prolonged S1BF activation. Habituation led to a significant BOLD magnitude decline as a function of time while both total ÎCMRGlc and ÎCMRO2 remained constant revealing adaptation of glucose and oxygen metabolisms to support ongoing trigeminal nerve stimulation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 346, 27 March 2017, Pages 337-348
Journal: Neuroscience - Volume 346, 27 March 2017, Pages 337-348
نویسندگان
Sarah Sonnay, João M.N. Duarte, Nathalie Just,