کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5738104 1615046 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Research articleInvestigation of left and right lateral fluid percussion injury in C57BL6/J mice: In vivo functional consequences
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Research articleInvestigation of left and right lateral fluid percussion injury in C57BL6/J mice: In vivo functional consequences
چکیده انگلیسی


- Left or right lateral TBI impaired MWM memory performance.
- Right lateral TBI produced modest MWM acquisition deficits compared to left.
- Both Left and right TBI produced similar neurological motor task deficits.
- Both left and right TBI produced impaired righting times and lesion volumes.
- Both left and right lateral TBI produced robust ipsilateral glial cell reactivity.

Although rodent models of traumatic brain injury (TBI) reliably produce cognitive and motor disturbances, behavioral characterization resulting from left and right hemisphere injuries remains unexplored. Here we examined the functional consequences of targeting the left versus right parietal cortex in lateral fluid percussion injury, on Morris water maze (MWM) spatial memory tasks (fixed platform and reversal) and neurological motor deficits (neurological severity score and rotarod). In the MWM fixed platform task, right lateral injury produced a small delay in acquisition rate compared to left. However, injury to either hemisphere resulted in probe trial deficits. In the MWM reversal task, left-right performance deficits were not evident, though left lateral injury produced mild acquisition and probe trial deficits compared to sham controls. Additionally, left and right injury produced similar neurological motor task deficits, impaired righting times, and lesion volumes. Injury to either hemisphere also produced robust ipsilateral, and modest contralateral, morphological changes in reactive microglia and astrocytes. In conclusion, left and right lateral TBI impaired MWM performance, with mild fixed platform acquisition rate differences, despite similar motor deficits, histological damage, and glial cell reactivity. Thus, while both left and right lateral TBI produce cognitive deficits, laterality in mouse MWM learning and memory merits consideration in the investigation of TBI-induced cognitive consequences.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 653, 13 July 2017, Pages 31-38
نویسندگان
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