کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5738827 1615059 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
C1473G polymorphism in mouse tryptophan hydroxylase-2 gene in the regulation of the reaction to emotional stress
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
C1473G polymorphism in mouse tryptophan hydroxylase-2 gene in the regulation of the reaction to emotional stress
چکیده انگلیسی
Neurotransmitter serotonin (5-HT) is involved in the regulation of stress response. Tryptophan hydroxylase-2 (TPH2) is the key enzyme of serotonin (5-HT) synthesis in the brain. C1473G polymorphism in Tph2 gene is the main factor defining the enzyme activity in the brain of laboratory mice. The effect of interaction between C1473G polymorphism and 30 min restriction stress on the behavior in the open field test, c-Fos gene expression and 5-HT metabolism in the brain in adult male of B6-1473C and B6-1473G congenic mouse lines with high and low TPH2 activity was investigated. A significant effect of genotype x stress interaction on c-Fos mRNA in the hypothalamus (F1,21 = 10.66, p < 0.001) and midbrain (F1,21 = 9.18, p < 0.01) was observed. The stress-induced rise of c-Fos mRNA in these structures is more intensive in B6-1473G than in B6-1473C mice. A marked effect of genotype x stress interaction on 5-HT level in the cortex (F1,18 = 9.38, p < 0.01) and 5-HIAA/5-HT turnover rate in the hypothalamus (F1,18 = 9.01, p < 0.01) was revealed. The restriction significantly decreased 5-HT level in the cortex (p < 0.01) and increased 5-HIAA/5-HT rate (p < 0.001) in the hypothalamus in B6-1473C mice, but not in B6-1473G mice. The present result is the first experimental evidence that C1473G polymorphism is involved in the regulation of the reaction to emotional stress in mice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Letters - Volume 640, 15 February 2017, Pages 105-110
نویسندگان
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