کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5746373 | 1618800 | 2017 | 6 صفحه PDF | دانلود رایگان |
- PCOS is caused by a combination of genetic susceptibility and environmental exposures.
- Patients with PCOS had higher p,pâ²-DDT (PÂ =Â 0.016) and o,pâ²-DDT levels than the controls.
- o,pâ²-DDT may play a role in the pathogenesis of PCOS related with reproductive hormone levels.
To investigate the serum concentrations of organochlorine pesticides (OCPs) in patients with polycystic ovary syndrome (PCOS), a total of 178 women were studied. The concentrations of hexachlorocyclohexane (HCH) and dichlorodiphenyltrichloroethane (DDT) in serum were determined using Gas Chromatography Mass-Mass Spectrometer. No differences with statistical significance in the mean HCH, p,pâ²-DDD, p,p'-DDE concentrations were observed between the patients with PCOS and the control group. Serum p,pâ²-DDT (PÂ =Â 0.016) and o,pâ²-DDT (PÂ =Â 0.000) levels were significantly higher in patients with PCOS compared with the control group. The results of the association between OCPs levels and hormone levels indicated that o,pâ²-DDT may play a role in the pathogenesis of PCOS by affecting hormones levels. Further trials should be investigated with the findings in this study to obtain new pathogenesis of PCOS.
Journal: Chemosphere - Volume 171, March 2017, Pages 595-600