کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5747326 | 1618797 | 2017 | 12 صفحه PDF | دانلود رایگان |
- Myxol glycosides from cyanobacteria were identified as teratogenic in the zebrafish embryo model.
- Comparison to other carotenoids and retinoids shows congener-specific teratogenicity.
- A model of teratogenicity of carotenoids as pro-retinoids is proposed.
- Relevance of teratogenicity to declines in aquatic vertebrates is discussed.
Toxigenicity of cyanobacteria is widely associated with production of several well-described toxins that pose recognized threats to human and ecosystem health as part of both freshwater eutrophication, and episodic blooms in freshwater and coastal habitats. However, a preponderance of evidence indicates contribution of additional bioactive, and potentially toxic, metabolites. In the present study, the zebrafish (Danio rerio) embryo was used as a model of vertebrate development to identify, and subsequently isolate and characterize, teratogenic metabolites from two representative strains of C. raciborskii. Using this approach, three chemically related carotenoids - and specifically the xanthophyll glycosides, myxol 2â²-glycoside (1), 4-ketomyxol 2â²-glycoside (2) and 4-hydroxymyxol 2â²-glycoside (3) - which are, otherwise, well known pigment molecules from cyanobacteria were isolated as potently teratogenic compounds. Carotenoids are recognized “pro-retinoids” with retinoic acid, as a metabolic product of the oxidative cleavage of carotenoids, established as both key mediator of embryo development and, consequently, a potent teratogen. Accordingly, a comparative toxicological study of chemically diverse carotenoids, as well as apocarotenoids and retinoids, was undertaken. Based on this, a working model of the developmental toxicity of carotenoids as pro-retinoids is proposed, and the teratogenicity of these widespread metabolites is discussed in relation to possible impacts on aquatic vertebrate populations.
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Journal: Chemosphere - Volume 174, May 2017, Pages 478-489