کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5751329 1619701 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Different effects of bisphenol a and its halogenated derivatives on the reproduction and development of Oryzias melastigma under environmentally relevant doses
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست شیمی زیست محیطی
پیش نمایش صفحه اول مقاله
Different effects of bisphenol a and its halogenated derivatives on the reproduction and development of Oryzias melastigma under environmentally relevant doses
چکیده انگلیسی


- Effects of BPA, TBBPA and TCBPA were compared.
- TCBPA was the most toxic to hatching, followed by TBBPA and BPA.
- Long term BPA exposure affected the reproductive ability rather than H-BPAs.
- Developmental stages affected the responses of gene expression to exposure.

Bisphenol A (BPA) and its halogenated compounds (H-BPAs) are widely detected in the environmental media and organisms. However, their toxicological effects, especially chronic exposure at low doses, have not been fully compared. In this study, the effects of BPA and H-BPAs on the reproduction and development of Oryzias melastigma were systematically assessed and compared at various developmental stages. BPA and its derivatives tetrabromobisphenol A (TBBPA) and tetrachlorobisphenol A (TCBPA) elicited the acceleration of embryonic heartbeat. BPA did not show any significant impact on the hatching time and rate of embryos. In contrast, both TBBPA and TCBPA led to the delayed hatching and decreased hatching rate. Accordingly, the expressions of hatching enzyme significantly decreased upon exposure and TCBPA was found to be more toxic than TBBPA. The body weight and gonadsomatic index (GSI) of the treated fish were relatively lower than the control fish upon long-term (four months from larvae to adult) exposure to BPA rather than H-BPAs. Slowed oocyte development occurred in the ovary, and the estrogen level decreased after exposure to BPA rather than H-BPAs. In male fish, no significant alteration was observed in the testis for all groups. The concentration of testosterone significantly decreased upon exposure to BPA rather than H-BPAs. The effects of these three chemicals on the estrogen-related gene expressions were different under various developmental stages. Our study indicated the importance of considering both the exposure stages and structure-activity relationship when assessing the eco-toxicological impact of pollutants.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Science of The Total Environment - Volume 595, 1 October 2017, Pages 752-758
نویسندگان
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