کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5797465 1111753 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The evolving cancer stem cell paradigm: Implications in veterinary oncology
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم دامی و جانورشناسی
پیش نمایش صفحه اول مقاله
The evolving cancer stem cell paradigm: Implications in veterinary oncology
چکیده انگلیسی


- Experimental evidence supports the cancer stem cell model.
- Lineage tracing and clonal analysis experiments support the clonal evolution and the cancer stem cell models.
- Drugs that can target cancer stem cells could have clinical benefits.

The existence of subpopulations of cells in cancer with increased tumour-initiating ability, self-renewal potential, and intrinsic resistance to conventional therapeutics formed the basis of the cancer stem cell model. Some tumours have since been viewed as aberrant tissues with a unidirectional hierarchical structure consisting of cancer stem cells at the apex, driving tumour growth, metastasis and relapse after therapy. Here, recent developments in cancer stem cell research are reviewed with a focus on tumour heterogeneity, cellular plasticity and cancer stem cell reprogramming. The impact of these findings on the cancer stem cell model is discussed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Veterinary Journal - Volume 205, Issue 2, August 2015, Pages 154-160
نویسندگان
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