Constitutively active group I mGlu receptors and PKMzeta regulate synaptic transmission in developing perirhinal cortex

► Synapses are in a constitutive LTP-like state in the developing perirhinal cortex. ► PKMζ inhibition reduces synaptic transmission in the developing perirhinal cortex. ► Group-I mGlu receptors support the LTP-like state in the perirhinal cortex. ► PKMζ, PI3Kinase and mTOR are down stream of group-I mGlu receptors.