CB1 receptor-dependent and -independent inhibition of excitatory postsynaptic currents in the hippocampus by WIN 55,212-2

These data suggest that, in the hippocampus, WIN 55,212-2 reduces glutamate release from Schaffer collaterals solely via CB1Rs in the nM concentration range, whereas in μM concentrations, WIN 55,212-2 suppresses excitatory transmission, in addition to activation of CB1Rs, by directly blocking N-type voltage-gated Ca2+ channels independent of CB1Rs.