کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
581631 | 1453159 | 2009 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Stripping voltammetric behaviour of toxic drug nitrofurantoin
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی شیمی
بهداشت و امنیت شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A simple, sensitive and reproducible squarewave cathodic adsorptive stripping voltammetric method has been developed for the determination of nitrofurantoin in solubilized system. The objective of the present paper is to investigate the redox behaviour of nitrofurantoin by using different voltammetric techniques and to establish the methodology for its determination in the presence of surfactants. Voltammograms of the drug with cetrimide in phosphate buffers of pH 2-11 exhibited a single well-defined reduction peak which may be attributed to the reduction of -NO2 group. The reduction process is irreversible over the entire pH range studied. The mechanism of reduction has been postulated on the basis of controlled potential electrolysis, coulometry and spectral analysis. The proposed SWCAdSV voltammetric method allows the determination of nitrofurantoin in linear concentration range 2 Ã 10â5 to 1 Ã 10â7 mol Lâ1. The lower limit of detection (LOD) and lower limit of quantification (LOQ) are 0.06 and 0.27 ng/mL, respectively.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Hazardous Materials - Volume 169, Issues 1â3, 30 September 2009, Pages 667-672
Journal: Journal of Hazardous Materials - Volume 169, Issues 1â3, 30 September 2009, Pages 667-672
نویسندگان
Rajeev Jain, Ashish Dwivedi, Ritesh Mishra,