کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5823753 | 1118353 | 2013 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Oxysterol-binding proteins: Functions in cell regulation beyond lipid metabolism
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کلمات کلیدی
ORPOSBP-related proteinPhosphatidylinositol-4-phosphateMCsERKFFATOHCVAMPVAPPI4POSBPtwo phenylalanines in an acidic tract - دو فنیلالانین در یک دستگاه اسیدیmembrane contact site - سایت تماس غشاییendoplasmic reticulum - شبکه آندوپلاسمی Plasma membrane - غشای پلاسماPhosphatidylinositol phosphate - فسفاتیدیلینواستات فسفاتhydroxycholesterol - هیدروکسی کلسترولORD - واژهlate endosome - پایان آندوسومOxysterol-binding protein - پروتئین اتصال دهنده اکسسترینVesicle-associated membrane protein - پروتئین غشاء مرتبط با VesiclePiP - پیپextracellular signal-regulated kinase - کیناز تنظیم شده سیگنال خارج سلولی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Oxysterol-binding (OSBP)-related proteins (ORPs) constitute a family of sterol and phosphoinositide binding/transfer proteins in eukaryotes from yeast to man. While their functions have mainly been addressed in cellular lipid metabolism or sterol transport, increasing evidence points to more versatile regulatory roles in a spectrum of cellular regimes. In fact ORPs do not appear to be robust controllers of lipid homeostasis. Several ORPs localize at membrane contacts sites (MCS), where endoplasmic reticulum (ER) is apposed with other organelle limiting membranes. Apparently, ORPs have the capacity to control the formation of MCS or activity of enzymatic machineries at these sites. Thereby, ORPs most likely affect organelle membrane lipid compositions, with impacts on signaling and vesicle transport, but also cellular lipid metabolism. Moreover, an increasing number of protein interaction partners of ORPs have been identified, connecting these proteins with various aspects of cell regulation. Small molecular anti-proliferative compounds, ORPphilins, were recently found to target two members of the ORP family, OSBP and ORP4, revealing an essential function of ORPs in cancer cell proliferation and survival. Further functions assigned for ORPs include regulation of extracellular signal regulated kinase (ERK) activity (OSBP), control of ER-late endosome MCS and late endosome motility (ORP1L), regulation of β1-integrin activity (ORP3), modulation of hepatocyte insulin signaling and macrophage migration (ORP8), as well as post-Golgi vesicle transport, phosphatidylinositol-4-phosphate and target of rapamycin complex 1 signaling and nitrogen sensing (Saccharomyces cerevisiae Osh4p). These and other recent observations shed light on the ORPs as integrators of lipid signals with an unforeseen variety of vital cellular processes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical Pharmacology - Volume 86, Issue 1, 1 July 2013, Pages 89-95
Journal: Biochemical Pharmacology - Volume 86, Issue 1, 1 July 2013, Pages 89-95
نویسندگان
Marion Weber-Boyvat, Wenbin Zhong, Daoguang Yan, Vesa M. Olkkonen,