کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5832711 | 1122607 | 2014 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Clinical relevance of post-transplant pharmacodynamic analysis of cyclosporine in renal transplantation
ترجمه فارسی عنوان
ارتباط بالینی تجزیه و تحلیل فارماکودینامیک پس از پیوند سیکلوسپورین در پیوند کلیه
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کلمات کلیدی
EGFRCFSEVZVCNINFATIC50PRDMMFMPA50% inhibitory concentration - 50٪ غلظت مهاریAUC - AUCHuman leukocyte antigen - آنتی ژن لوسکسی انسانHLA - آنتیژن گلبول سفید انسانیCSA - ایالات مؤتلفهٔ آمریکاCMV - سیتومگالوویروسcytomegalovirus - سیتومگالوویروسCyclosporine - سیکلوسپورینNuclear Factor of Activated T Cells - عامل هسته ای سلول های T فعال شدهPharmacodynamics - فارماکودینامیکmycophenolate mofetil - مایکوفنولات موفتیلmycophenolic acid - مایکوفنولیک اسید، مایکوفنولاتcalcineurin inhibitor - مهار کننده کالسینورینestimated glomerular filtration rate - میزان تصفیه گلومرولی برآورد شده استVaricella zoster virus - ویروس واریسلا زوسترPrednisolone - پردنیزولونRenal transplantation - پیوند کلیه
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
چکیده انگلیسی
Although therapeutic drug monitoring based on blood concentration has been widely implemented in transplant recipients treated with immunosuppressive agents, clinical adverse events such as rejection, infection or drug-induced toxicity caused by inappropriate dosage cannot be completely controlled. Development of an effective assay for optimized immunosuppression would be desirable, which can potentially lead to personalized medicine in renal transplantation. Cyclosporine (CSA) pharmacodynamic analysis using carboxyfluorescein diacetate succinimidyl ester (CFSE)-based T cell proliferation assay was examined in 66 kidney transplant recipients before and after transplantation. Two parameters, the 50% inhibitory concentration (IC50) and the percentage of T-cell proliferation values at the lower plateau (bottom), were compared with clinical events. A significant relation in CSA pharmacodynamic parameters was observed between pre- and post-transplantation. Analysis of the association between clinical outcomes and pharmacodynamic parameters in post-transplant samples demonstrated the following findings: (i) cytomegalovirus (CMV)/varicella zoster virus (VZV) reactivation and CSA-induced nephrotoxicity were significantly associated with high sensitivity to CSA (low bottom or low IC50), (ii) acute T cell-mediated rejection (ATMR) was significantly related to low sensitivity to CSA (high bottom), and (iii) de novo human leukocyte antigen (HLA) antibody production was associated with lower bottom and IC50 values, although the elucidation of those mechanisms is still in progress. It was suggested that CSA pharmacodynamics applied at post-transplantation would be useful for optimizing immunosuppressive therapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Immunopharmacology - Volume 22, Issue 2, October 2014, Pages 384-391
Journal: International Immunopharmacology - Volume 22, Issue 2, October 2014, Pages 384-391
نویسندگان
Yoko Kurata, Takafumi Kuzuya, Yuko Miwa, Kenta Iwasaki, Masataka Haneda, Katsuo Amioka, Kiyofumi Yamada, Yoshihiko Watarai, Akio Katayama, Kazuharu Uchida, Takaaki Kobayashi,