Effect of acute and chronic insulin administrations on major factors involved in the control of muscle protein turnover in rainbow trout (Oncorhynchus mykiss)

► Acute insulin injection affects several factors of muscle protein turnover in trout. ► The phosphorylation of IRS1, TOR and 4E-BP1 are induced by acute insulin injection. ► The proteasomal and calpastatin genes are down regulated by acute insulin injection. ► Autophagy-related genes remained unaffected. ► Chronic insulin treatment leads to an insulin resistance state of trout muscle.