کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
59148 1419420 2016 9 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله ISI
An environmentally-friendly base organocatalyzed one-pot strategy for the regioselective synthesis of novel 3,6-diaryl-4-methylpyridazines
ترجمه فارسی عنوان
یک استراتژی تک ظرفی پایگاه سازگار با محیط زیست برای سنتز regioselective 3,6-diaryl-4-methylpyridazines جدید
کلمات کلیدی
1,4-Diazabicyclo[2.2.2]octane (DABCO)؛ پروپیوفنون؛ Arylglyoxalmonohydrate؛ پیریدازین
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی کاتالیزور
چکیده انگلیسی

This report describes a new three-component strategy for the regioselective synthesis of a series of tri-substituted pyridazines via a 1,4-diazabicyclo[2, 2 and 2]octane (DABCO)-catalyzed condensation of propiophenones, arylglyoxalmonohydrates and hydrazine hydrate in water. This method provides a green and convenient one-pot route toward a diverse set of 3,6-diaryl-4-methylpyridazines bearing various aryl substituents. This procedure is highly regioselective, operationally simple, uses water as a safe, environmentally friendly solvent, and DABCO as a green base-organocatalyst, and affords good to excellent yields of products.

Graphical AbstractThis work describes the regioselective synthesis of novel 3,6-diaryl-4-methylpyridazines directly from a DABCO-catalyzed three-component condensation of propiophenones, arylglyoxalmonohydrates and hydrazine hydrate in water.Figure optionsDownload as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Journal of Catalysis - Volume 37, Issue 4, April 2016, Pages 517–525
نویسندگان
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