Monoaminergic signaling as a target for anthelmintic drug discovery: Receptor conservation among the free-living and parasitic nematodes

► Monoamines modulate sensory-mediated locomotory behavior in nematodes. ► Exogenous monoamines can paralyze both free-living and parasitic nematodes. ► Monoamine receptors are conserved in both free-living and parasitic nematodes. ► Monoamine receptors may be useful targets for anthelmintic design.