Testing the cumulative stress and mismatch hypotheses of psychopathology in a rat model of early-life adversity

► Early-life adversity programs psychosis susceptibility. ► Corticosterone exposure facilitates expression of psychosis behavioral markers. ► Post-weaning social isolation attenuates the impact high early-life adversity load. ► Post-weaning social housing enhances the impact high early-life adversity load. ► Mismatch or cumulative stress outcome depends on the combination of environmental inputs.