کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
593987 | 1453959 | 2012 | 6 صفحه PDF | دانلود رایگان |
Magnetic micro/nanoparticles have great potential to be used in drug delivery and magnetic hyperthermia for cancer therapy. Here we report a novel chemical approach for the fabrication of protein-coated FeNi3 particles for use as thermal therapeutic agents. The particles are composed of metallic FeNi3 cores and coated with bovine serum albumin (BSA). The FeNi3@BSA composite particles demonstrate typical ferromagnetism with saturation magnetization (Ms) about 50 emu/g and coercivity 150 Oe or so. Due to the encapsulation of protein layer, the FeNi3@BSA composite particles exhibit low toxicity and superior biocompatibility. As-prepared FeNi3@BSA particles demonstrate higher heating efficiency compared with that of superparamagnetic ferrite nanoparticles (NPs).
Ferromagnetic FeNi3@BSA core@shell structured microspheres have been prepared by a novel ethanol-induced degeneration method. Due to the encapsulation of protein layer, the FeNi3@BSA composite particles exhibit low toxicity and superior biocompatibility. Moreover, as-prepared FeNi3@BSA particles possess typical ferromagnetism and demonstrate higher heating efficiency compared with that of superparamagnetic ferrite nanoparticles.Figure optionsDownload as PowerPoint slideHighlights
► A novel ethanol-induced degeneration method is proposed to prepare FeNi3@BSA particles.
► The FeNi3@BSA particles possess ferromagnetism with Ms about 50 emu/g and coercivity 150 Oe.
► The FeNi3@BSA composite particles exhibit low toxicity and superior biocompatibility.
► The particles demonstrate higher heating efficiency compared with that of ferrite NPs.
Journal: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Volume 414, 20 November 2012, Pages 168–173