کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5985196 | 1178771 | 2016 | 11 صفحه PDF | دانلود رایگان |
BackgroundOptimizing plasma lipoproteins is the primary goal of pharmacotherapy and diet interventions in people at risk for cardiovascular diseases. Avocados offer a rich source of monounsaturated fat and may pose beneficial effects on the lipid profile.ObjectiveWe aimed to perform a meta-analysis of randomized clinical trials assessing the impact of avocados on TC, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol, and/or triglycerides (TG).MethodsWe searched PUBMED, Cumulative Index to Nursing and Allied Health Literature, Index to Nursing and Allied Health Literature, and the Cochrane Database of Systemic Reviews from their inception to February 2015. The weighted mean difference from baseline was calculated for all endpoints. Subgroup analyses were performed to assess heterogeneity, and funnel plots inspected to assess publication bias.ResultsTen unique studies (n = 229) were included. Avocado consumption significantly reduced TC, LDL-C, and TG by â18.80 mg/dL (95% confidence interval [CI], â24.56 to â13.05; I2, 46.9%), â16.50 mg/dL (95% CI, â22.91 to â10.10; I2, 72.5%), â27.20 mg/dL (95% CI, â44.41 to â9.99; I2, 91.1%) respectively. High-density lipoprotein cholesterol decreased nonsignificantly by â0.18 mg/dL (95% CI, â3.23 to 2.88; I2, 84.8%).ConclusionAvocado-substituted diets significantly decrease TC, LDL-C, and TG levels. Substituting dietary fats with avocados versus adding to the free diet should be the primary recommendation strategy. Larger trials looking at the impact of avocados on major adverse cardiovascular events are warranted.
Journal: Journal of Clinical Lipidology - Volume 10, Issue 1, JanuaryâFebruary 2016, Pages 161-171