Folate-polydiacetylene-liposome for tumor targeted drug delivery and fluorescent tracing

• Folic acid is modified with dodecylamine and embedded in bilayer by alkane chain.
• Folate-PDA-liposome with targeted delivery and fluorescence tracing was prepared.
• Simulated drug delivery was performed in cancer cells and normal cells in vitro.
• Internalization of FPLs in cells was presented by fluorescence cell imaging.

A novel folate-polydiacetylene-liposome (FP-PL) with both targeted drug delivery and fluorescence tracing was prepared by thin film rehydration method. The simulated drug delivery was performed in Bcap-37 breast cancer cells and Hs578Bst normal cells in vitro. The internalization and distribution of FP-PLs in the cells were presented by fluorescence cell imaging. The results show that the FP-PLs possess low cytotoxicity, good biocompatibility and better targeting efficiency in comparison to polydiacetylene-liposomes (P-PLs).

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