کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6010361 | 1185876 | 2015 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Experiencing neonatal maternal separation increased the seizure threshold in adult male mice: Involvement of the opioid system
ترجمه فارسی عنوان
تجربیات جدایی مادران نوزاد، آستانه تشنج در موشهای نر بالغ را افزایش داد: مشارکت سیستم اپیویید
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
چکیده انگلیسی
Experiencing early-life stress has been considered as a potent risk factor for the development of many of brain disorders, including seizures. Intervening mechanisms through which neonatal maternal separation (MS) alters the seizure susceptibility in adulthood have not been well studied. In the current study, by applying 180Â min of MS stress (PND 2-14), we determined the seizure susceptibility and considered the role of the opioid system. Maternal separation increased the seizure threshold, and administration of anticonvulsant/proconvulsant doses of morphine (1 and 30Â mg/kg, respectively) reversed the impact of MS. Using tail flick and hot plate tests, we exposed animals to 30Â min Restraint stress (RS) and found that MS decreased the pain threshold, suggesting the hyporesponsiveness of the opioid system. These results supported the abnormal seizure activity observed in the MS mice and suggested that abnormalities in the opioid system following MS alter seizure susceptibility in later life.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy & Behavior - Volume 52, Part A, November 2015, Pages 37-41
Journal: Epilepsy & Behavior - Volume 52, Part A, November 2015, Pages 37-41
نویسندگان
Hossein Amini-Khoei, Shayan Amiri, Armin Shirzadian, Arya Haj-Mirzaian, Sakineh Alijanpour, Maryam Rahimi-Balaei, Ali Mohammadi-Asl, Mahsa Hassanipour, Shahram Ejtemaie Mehr, Ahmad Reza Dehpour,