کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6021058 | 1580435 | 2011 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
HIF-1α expression in the hippocampus and peripheral macrophages after glutamate-induced excitotoxicity
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Hypoxia-inducible factor-1 alpha (HIF-1α) is a master transcription factor that regulates the response to hypoxia and ischemia and induces the expression of various genes, including vascular endothelial growth factor (VEGF) and erythropoietin (EPO). This study shows the systemic response of increased HIF-1α, EPO, and VEGF mRNA and protein. In addition, VEGF expression was increased in neurons and over-expressed in glial cells in a model of neuroexcitotoxicity in the hippocampus, in which rats were neonatally exposed to high glutamate concentrations. Simultaneous increases in HIF-1α, EPO and VEGF mRNA in peritoneal macrophages were also observed. Our study is consistent with the hypothesis that these genes exert a protective effect in response to neurotoxicity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 238, Issues 1â2, 15 September 2011, Pages 12-18
Journal: Journal of Neuroimmunology - Volume 238, Issues 1â2, 15 September 2011, Pages 12-18
نویسندگان
E. Vazquez-Valls, M.E. Flores-Soto, V. Chaparro-Huerta, B.M. Torres-Mendoza, G. Gudiño-Cabrera, M.C. Rivera-Cervantes, M. Pallas, A. Camins, J. Armendáriz-Borunda, C. Beas-Zarate,