کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6024101 | 1580883 | 2016 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Diminished neural adaptation during implicit learning in autism
ترجمه فارسی عنوان
کاهش تطابق عصبی در یادگیری ضمنی در اوتیسم
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کلمات کلیدی
ROIMNIADI-RFunctional connectivity - اتصال عملکردی Autism spectrum disorder - اختلالات طیف اوتیسم گروهیAutism Diagnostic Observation Schedule - برنامه ریزی تشخیص اوتیسمfunctional magnetic resonance imaging - تصویرسازی تشدید مغناطیسی کارکردیregion of interest - منطقه مورد نظرMontreal Neurological Institute - موسسه عصبی مونترالASD - نقص سپتوم یا دیوارهی دهلیزیADOS - نوجوانانPrototype - پیش نمونه، پروتوتایپImplicit learning - یادگیری ضمنی، یادگیری پنهان
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب شناختی
چکیده انگلیسی
Neuroimaging studies have shown evidence of disrupted neural adaptation during learning in individuals with autism spectrum disorder (ASD) in several types of tasks, potentially stemming from frontal-posterior cortical underconnectivity (Schipul et al., 2012). The aim of the current study was to examine neural adaptations in an implicit learning task that entails participation of frontal and posterior regions. Sixteen high-functioning adults with ASD and sixteen neurotypical control participants were trained on and performed an implicit dot pattern prototype learning task in a functional magnetic resonance imaging (fMRI) session. During the preliminary exposure to the type of implicit prototype learning task later to be used in the scanner, the ASD participants took longer than the neurotypical group to learn the task, demonstrating altered implicit learning in ASD. After equating task structure learning, the two groups' brain activation differed during their learning of a new prototype in the subsequent scanning session. The main findings indicated that neural adaptations in a distributed task network were reduced in the ASD group, relative to the neurotypical group, and were related to ASD symptom severity. Functional connectivity was reduced and did not change as much during learning for the ASD group, and was related to ASD symptom severity. These findings suggest that individuals with ASD show altered neural adaptations during learning, as seen in both activation and functional connectivity measures. This finding suggests why many real-world implicit learning situations may pose special challenges for ASD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 125, 15 January 2016, Pages 332-341
Journal: NeuroImage - Volume 125, 15 January 2016, Pages 332-341
نویسندگان
Sarah E. Schipul, Marcel Adam Just,