Mapping directionality specific volume changes using tensor based morphometry: An application to the study of gyrogenesis and lateralization of the human fetal brain

► Mathematical framework to detect anisotropic brain volume changes. ► Framework includes two novel descriptors to quantify directionality of volume change. ► Used, with TBM, to model population-wide patterns in brain morphological changes. ► Used to map local patterns of directional growth in fetal human brain. ► Also used to map directional hemispheric asymmetry in growth.