PET imaging of cholinergic deficits in rats using [18F]fluoroethoxybenzovesamicol ([18F]FEOBV)

► Assessing [18F]FEOBV as a marker for presynaptic cholinergic transmission in rats ► Highest binding was found in the striatum, cortex, hippocampus and thalamus. ► Lesion of the nucleus basalis of Meynert induced lower binding in cortex. ► Aged rats showed decreased binding in the hippocampi.