In vivo mapping of brain myo-inositol

►Hydroxyl protons on Myo-Inositol (MI) exhibit chemical exchange saturation transfer (CEST) effect. ►CEST effect of MI (MICEST) can be imaged at high field MRI scanner. ►The magnitude of the MICEST contrast is highly dependent on the pH, MI concentration and saturation pulse parameters. ►It is demonstrated that MICEST detection is feasible in the human brain at ultra high fields (7 T) without exceeding the allowed limits on radiofrequency specific absorption rate.