Effects of aroma compounds and lipid composition on release of functional substances encapsulated in nanostructured lipid carriers lipolyzed by lipase

• Chemical structures have a marked effect on the anti-lipase activity of the tested aroma compounds.
• Lipid type, composition, and a lipase inhibitor affect the release rate of curcumin from NLC.
• Lipase shows a preference for lipid with higher digestibility in a lipid mixture during lipolysis.

Nanostructured lipid carriers (NLC) are a delivery system for drugs or functional substances to control their release and protect them from harmful environmental stresses. The aims of this research were to investigate the effects of chemical structure of aroma compounds, type and composition of lipids as well inhibitors on the lipolysis of NLC in the presence of lipase, and to study the release rate of a functional substance, curcumin, encapsulated in the NLC by a kinetic study. The amount of free fatty acids released from the lipid digestion of NLC was determined by a pH-stat method. Franz diffusion cells were used to study the release rate of curcumin from the digestion of NLC by the lipase in the presence or absence of an inhibitor. The results indicate that the chemical structures of the tested aroma compounds have a marked effect on the inhibition of lipase activity. In addition, the release rate of functional substances such as curcumin encapsulated in the NLC can be controlled by manipulating the lipid type and composition, and using a lipase inhibitor.

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