کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6087603 | 1207374 | 2013 | 11 صفحه PDF | دانلود رایگان |
- Dex induces apoptosis on Tregs, with negligible effect on Teff.
- Dex induces a greater inhibition of the Teff proliferation.
- Activation and/orIL-2 modulates Dex inhibitory effects on the Tregs compartment.
- Dex does not affect the suppressor function of Tregs.
It is assumed that the ratio between effector T cells (Teff) and regulatory T cells (Tregs) controls the immune reactivity within the T-cell compartment. The purpose of this study was to investigate if Dexamethasone (Dex) affects Teff and Tregs subsets. Dex induced on Tregs a dose and time-dependent apoptosis which resulted in a relative increase of Teff. After TCR activation, Dex induced a strong proliferative inhibition of Teff, but a weaker proliferative inhibition on Tregs. These effects were modulated by IL-2, which not only restored the proliferative response, but also prevented Dex-induced apoptosis. The highest dose of IL-2 prevented apoptosis on all FOXP3Â +Â CD4Â + T cells. Meanwhile, the lowest dose only rescued activated Tregs (aTregs), probably related to their CD25 higher expression. Because Dex did not affect the suppressor capacity of aTregs either, our results support the notion that under Dex treatment, the regulatory T-cell compartment maintains its homeostasis.
Journal: Clinical Immunology - Volume 149, Issue 3, Part B, December 2013, Pages 400-410