Substituent effect on the emission behavior of thiazolidinedione derivatives in cationic and anionic micellar media

Thiazolidinedione (TZD) derivatives have been found to possess potent immunostimulatory properties as well as antiarthritic, antidiabetic and oncostatic activities. These compounds are free radical scavengers. Photophysical properties of the compounds have been studied in different aqueous micellar environments using steady state and time resolved emission spectroscopy. Appreciable hypsochromic shifts with enhancement in the fluorescence intensities have been observed in the ionic micellar media. The binding constants and energy changes during probe–micelle binding have been evaluated from relevant fluorescence data. Polarity of the microenvironment surrounding the probe molecules has been determined in the micellar systems.

Existence of the rotameric forms of this thiazolidinedione derivative (TZD A) results in unique behavior compared to other related derivatives.Figure optionsDownload as PowerPoint slide