کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6116987 | 1591554 | 2016 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Intrinsic features of the CD8뱉 dendritic cell subset in inducing functional T follicular helper cells
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
T follicular helper (Tfh) cells, a true B cell helper, have a critical role in enhancing humoral immune responses. However, the initial differentiation of Tfh cells by dendritic cells (DCs), the most potent antigen presenting cells, has not been clearly understood, particularly in the knowledge of the two major conventional dendritic cell subsets, CD8α+ DCs or CD8αâ DCs. Here we demonstrated that the localization of CD8αâ DCs in the marginal zone (MZ) bridging channels is closely associated with the induction of CXCR5+CCR7low Tfh cells. We also showed that the major source of IL-6 for inducing Tfh cells is provided from the activated CD4+ T cells induced by CD8αâ DCs, and IL-6 directly secreted from the DC subsets seems minor. CD8αâ DCs were superior in inducing functional Tfh cells over other antigen presenting cells including B cells. We here observed the unknown intrinsic features of the DC subsets, suggesting the potential of utilizing the CD8αâ DC subset as therapeutic vaccine for the regulation of humoral immune responses.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunology Letters - Volume 172, April 2016, Pages 21-28
Journal: Immunology Letters - Volume 172, April 2016, Pages 21-28
نویسندگان
Changsik Shin, Jae-A Han, Bongseo Choi, Yoon-Kyoung Cho, Yoonkyung Do, Seongho Ryu,