کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6125870 | 1221035 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Carbohydrates and T cells: A sweet twosome
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کلمات کلیدی
IFN-γMajor histocompatibility class IIpolysaccharide ACPSsMHCIIiNKTα-GalCerDCsOVAiNOSIBDBCRTCrPSAAPCsantigen-presenting cells - آنتیژن ارائه سلولAntigen presentation - ارائه آنتیژنOvalbumin - اوبلبومینinterferon γ - اینترفرون γinterleukin - اینترلوکینInflammatory bowel disease - بیماریهای التهابی رودهtetanus toxoid - توکسوئین تانتانسT cell - سلول تیDendritic cells - سلول های دندریتیکinducible nitric oxide synthase - سنتاز اکسید نیتریک القاییGlycoconjugate vaccine - واکسن گلیکوکونژوگهCapsular polysaccharides - پلی ساکارید کپسولglycolipid - گلیکولیپیدGlycopeptide - گلیکوپپتیدreactive nitrogen species - گونه های واکنش پذیر نیتروژنB-cell receptor - گیرنده سلول BT-cell receptor - گیرنده لنفوسیت T
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Carbohydrates as T cell-activating antigens have been generating significant interest. For many years, carbohydrates were thought of as T-independent antigens, however, more recent research had demonstrated that mono- or oligosaccharides glycosidically linked to peptides can be recognized by T cells. T cell recognition of these glycopeptides depends on the structure of both peptide and glycan portions of the antigen. Subsequently, it was discovered that natural killer T cells recognized glycolipids when presented by the antigen presenting molecule CD1d. A transformative insight into glycan-recognition by T cells occurred when zwitterionic polysaccharides were discovered to bind to and be presented by MHCII to CD4+ T cells. Based on this latter observation, the role that carbohydrate epitopes generated from glycoconjugate vaccines had in activating helper T cells was explored and it was found that these epitopes are presented to specific carbohydrate recognizing T cells through a unique mechanism. Here we review the key interactions between carbohydrate antigens and the adaptive immune system at the molecular, cellular and systems levels exploring the significant biological implications in health and disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Immunology - Volume 25, Issue 2, April 2013, Pages 146-151
Journal: Seminars in Immunology - Volume 25, Issue 2, April 2013, Pages 146-151
نویسندگان
Fikri Y. Avci, Xiangming Li, Moriya Tsuji, Dennis L. Kasper,