کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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6240958 | 1280449 | 2013 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: A randomized controlled trial of inhaled l-Arginine in patients with cystic fibrosis A randomized controlled trial of inhaled l-Arginine in patients with cystic fibrosis](/preview/png/6240958.png)
BackgroundCystic fibrosis (CF) airways are nitric oxide (NO) deficient. We studied safety and efficacy of repeated inhalations of nebulized l-arginine, the substrate for NO synthase (NOS), in patients with CF.MethodsDouble-blind, randomized, placebo-controlled crossover treatment trial of twice daily inhalation of 500 mg l-arginine for two weeks compared to inhalation of saline in 19 CF patients (ClinicalTrials.gov Identifier: NCT00405665).Resultsl-Arginine inhalation was well tolerated and resulted in a significant increase in exhaled NO. FEV1 increased by an average of 56 ml compared to â 8 ml after saline solution; but this difference did not reach statistical significance. Sputum concentrations of l-ornithine, the product of arginase activity, increased significantly while the l-ornithine derived polyamines did not. There was no change in inflammatory markers in sputum.ConclusionRepeated inhalation of l-arginine in CF patients was safe and well tolerated. Inhaled l-arginine increased NO production without evidence for changes in airway inflammation.
Journal: Journal of Cystic Fibrosis - Volume 12, Issue 5, September 2013, Pages 468-474