کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6275228 1614839 2013 20 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Rhythmic theta and delta activity of cortical and hippocampal neuronal networks in genetically or pharmacologically induced N-methyl-d-aspartate receptor hypofunction under urethane anesthesia
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Rhythmic theta and delta activity of cortical and hippocampal neuronal networks in genetically or pharmacologically induced N-methyl-d-aspartate receptor hypofunction under urethane anesthesia
چکیده انگلیسی
► Pharmacologically and genetically induced NMDAR hypofunction was assessed in rats and mice. ► MK-801 reduced both spontaneous and elicited hippocampal theta power. ► Grin1 mice showed similar neurophysiological abnormalities to MK-801-treated mice. ► AMPA-PAM improved both in pharmacological and genetic NMDA hypofunction models. ► Models proposed for glutamate-targeting drug candidate evaluation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 237, 1 May 2013, Pages 255-267
نویسندگان
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