کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6277751 | 1295775 | 2009 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The distribution of γ-hydroxybutyrate-induced Fos expression in rat brain: Comparison with baclofen
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کلمات کلیدی
MFBLHbNTSPBHSWSMDMAREMNREMGBLVTAc-fosγ-HydroxybutyrateMNPOGHBVLPOTHCPBS3,4-methylenedioxymethamphetamine - 3،4-methylenedioxymethamphetamineAUC - AUCMnR - MNRγ-butyrolactone - γ-بوتیرولاکتونphosphate buffer - بافر فسفاتmedial forebrain bundle - بسته نرم افزاری پروبیالanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of variancerapid eye movement - حرکت سریع چشمnon-rapid eye movement - حرکت سریع چشم نیستlateral habenula - حنابا جانبیSleep - خوابslow wave sleep - خواب کم آهستهMedian raphe - روحانی متوسطSON - فرزند پسرLocomotor activity - فعالیت locomotorPVN - مالیات بر ارزش افزودهPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریarea under the curve - منطقه تحت منحنیventral tegmental area - ناحیه تگمنتوم شکمیVentrolateral preoptic nucleus - هسته preoptic VentrolateralSupraoptic nucleus - هسته Supraopticnucleus of the solitary tract - هسته دستگاه انفرادیparaventricular nucleus of the hypothalamus - هسته پروانه مرکزی هیپوتالاموسmedian preoptic nucleus - هسته پیشوپتیک مدیاستReward - پاداشGABAB - گابابGamma-hydroxybutyrate - گاما هیدروکسی بوتیرات
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
γ-Hydroxybutyrate (GHB) is a euphoric, prosocial and sleep inducing drug that binds with high affinity to its own GHB receptor site and also more weakly to GABAB receptors. GHB is efficacious in the treatment of narcolepsy and alcoholism, but heavy use can lead to dependence and withdrawal. Many effects of GHB (sedation, hypothermia, catalepsy) are mimicked by GABAB receptor agonists (e.g. baclofen). However other effects (euphoric and prosocial effects and a therapeutic effect in narcolepsy) are not. The present study used Fos immunohistochemistry to assess the neural activation produced in rat brain by medium to high doses of GHB (250, 500 and 1000 mg/kg) and a high dose of baclofen (10 mg/kg) that produced similar sedation to 500 mg/kg GHB. Results showed many common regions of activation with these two drugs including the supraoptic, paraventricular, median preoptic and ventral premammillary nuclei of the hypothalamus, the central nucleus of the amygdala, Edinger-Westphal nucleus, lateral parabrachial nucleus, locus coeruleus, and nucleus of the solitary tract. GHB (500 mg/kg), but not baclofen (10 mg/kg), induced significant Fos expression in the median raphe nucleus and lateral habenula, while a higher dose of GHB (1000 mg/kg) induced additional Fos expression in the islands of Calleja, dentate gyrus (polymorphic layer) and arcuate nucleus, and in various regions implicated in rapid and non-rapid eye movement sleep (laterodorsal tegmental nucleus, tuberomammillary nucleus and the ventrolateral and anterodorsal preoptic nuclei). Surprisingly, Fos immunoreactivity was not observed with either GHB or baclofen in reward-relevant regions such as the nucleus accumbens, striatum and ventral tegmental area. Overall these results indicate a distinctive signature of brain activation with GHB that may be only partly due to GABAB receptor effects. This confirms a unique neuropharmacological profile for GHB and indicates key neural substrates that may underlie its characteristic influence on sleep, body temperature, sociability and endocrine function.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 158, Issue 2, 23 January 2009, Pages 441-455
Journal: Neuroscience - Volume 158, Issue 2, 23 January 2009, Pages 441-455
نویسندگان
P.S. van Nieuwenhuijzen, I.S. McGregor, G.E. Hunt,