کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
640224 1456962 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Separation and analysis of pharmaceuticals in cold drugs using green chromatography
ترجمه فارسی عنوان
جداسازی و تجزیه و تحلیل مواد دارویی در داروهای سرد با استفاده از کروماتوگرافی سبز
کلمات کلیدی
کروماتوگرافی سبز؛ کروماتوگرافی آب بحرانی؛ مواد مخدر سرد؛ داروها؛ استامینوفن؛ گایافنازین
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی تصفیه و جداسازی
چکیده انگلیسی


• Subcritical water chromatography replaced HPLC for separation of pharmaceuticals.
• Hazardous organic solvents are eliminated from subcritical water chromatography.
• Efficient separation of pharmaceuticals in real-world cold drugs was achieved.
• The recovery of pharmaceuticals ranges from 94% to 105% with less than 5% RSD.

Subcritical water chromatography (SBWC) can replace traditional HPLC for separation and analysis of pharmaceuticals. Because hazardous organic solvents are eliminated from the SBWC mobile phase, subcritical water chromatography is a green separation technique. In addition, SBWC is economical since the purchasing of organic solvents and waste disposal costs required for HPLC can be saved. In this work, pharmaceuticals present in cold drugs including Vicks formula 44 custom care, Alka-seltzer plus, and CVS multi-symptom severe cold relief were successfully separated using subcritical water chromatography on an Alltech Adsorbosil C18 column. Both gradient elution and programmed temperatures were employed to achieve the best SBWC separation of pharmaceuticals contained in the cold drug samples studied. The recoveries of pharmaceuticals in the three real-world cold drug samples achieved by SBWC range from 94% to 105% with less than 5% RSD.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Separation and Purification Technology - Volume 158, 28 January 2016, Pages 308–312
نویسندگان
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